Publikation: Dissertationsschrift

A systems biology approach to understand the influence of SORLA on amyloidogenic processing in Alzheimer's disease

Grunddaten
Links
Abstract
Autoren
Einrichtung

Grunddaten

Titel	A systems biology approach to understand the influence of SORLA on amyloidogenic processing in Alzheimer's disease
Erscheinungsjahr	2012
Publikationsform	Elektronische Ressource
Publikationsart	Dissertationsschrift
Sprache	Englisch
Letzte Änderung	25.04.2014 12:51:28
Bearbeitungsstatus	durch UB Rostock abschließend validiert
Dauerhafte URL	http://purl.uni-rostock.de/fodb/pub/44627
Links zu Katalogen

Abstract

In this dissertation APP processing is modelled and the influence of SORLA in Alzheimers disease is evaluated. A model with both monomeric and dimeric APP in a single compartment best fitted the experimental data suggesting that SORLA prevents APP oligomerization and affects b-secretase indirectly. Including compartmental details into the combined model, the multi-compartmental model determines the relative contribution of SORLA to each APP-cleavage step showing that SORLA specifically impairs the processing of APP dimer and alters the dynamical behavior of beta-secretase.

Autor

Lao, Angelyn

Externe Links

Beschreibung	Link
Metadaten	http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0075-4
Volltext (kostenfrei zugänglich ohne Registrierung)	http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0075-4&pdf
Link zur Online-Ressource	http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0075-4

Einrichtung

Fakultät für Informatik und Elektrotechnik (IEF)